Dry eye syndrome. dry eye syndrome
Conditions
Interventions
Intervention 1: Intervention group: ophthalmic probiotic drop, 1 drop Q6h, for 4 weeks. Intervention 2: Control group: ophthalmic placebo drop, 1 drop Q6h, for 4 weeks.
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Male or Female 18=9/10 Signed informed consent Voluntary adherence to treatment
Exclusion criteria
Exclusion criteria: Pregnancy/breastfeeding Conjunctivitis Thyroid disease Diabetes Rheumatologic diseases including Sjogren's syndrome Neurologic conditions, including stroke, Bell's palsy, Parkinson's, trigeminal nerve problem Refractive surgery (LASIK or PRK) Other Eye Surgeries HSV Keratitis Medication/supplement use, including psychiatric medicines, OTC cold medicines, anti-histamines, beta-blockers, pain relievers, sleeping pills, diuretics, Hormones replacement, and oral contraceptives Chemical splashes / injuries to the eyes Contact lens use Environmental (dusty, windy, hot/dry) Any treatment for dry eye in previous 4 weeks (including lubricants, steroids, cyclosporine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular Surface Disease Index. Timepoint: 4 weeks. Method of measurement: questionnaire.;Tear break up time (TBUT). Timepoint: 4 weeks. Method of measurement: Slit exam with fluorescein staining.;Schirmer test. Timepoint: 4 weeks. Method of measurement: Physical exam with Schirmer strip.;Ocular surface microbiota composition. Timepoint: 4 weeks. Method of measurement: Measured by 16s rRNA method.;Tear Interleukin level. Timepoint: 4 weeks. Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMojtaba Heydari
Shiraz University of Medical Sciences
Outcome results
None listed