Dry eye syndrome. Dry eye syndrome
Conditions
Interventions
Intervention 1: First intervention group: Participants in this group will receive 30 mg/day of standardized saffron extract. The daily dose will be divided into three equal doses of 10 mg and administ
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: OSDI score > 12 Schirmer test < 10 mm/5 minutes.
Exclusion criteria
Exclusion criteria: Corneal ulcer Glaucoma Autoimmune diseases Uncontrolled diabetes Pregnancy Breastfeeding Allergy or sensitivity to the study medications Previous eye surgery Cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular Surface Disease Index. Timepoint: Before the intervention and 4 , 8 weeks after intervention. Method of measurement: The OSDI questionnaire.;Tear Break-Up Time. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Physical exam with slit lamp.;Schirmer Test. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Measurement with Schirmer Test strip. | — |
Secondary
| Measure | Time frame |
|---|---|
| Tear IL1 level. Timepoint: 8 weeks. Method of measurement: Human Interleukin-1 ELISA Kit (Sigma-Aldrich).;Tear IL6 level. Timepoint: 8 weeks. Method of measurement: Human Interleukin-6 ELISA Kit (Sigma-Aldrich).;Tear TNF level. Timepoint: 8 weeks. Method of measurement: Human TNF ELISA Kit (Sigma-Aldrich). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMojtaba Heydari
Shiraz University of Medical Sciences
Outcome results
None listed