The effects of Platelet-Rich Plasma on the Recovery of Patients with Long Bone Fractures with Delayed Union

Investigating the effects of Platelet-Rich Plasma on the Recovery of Patients with Long Bone Fractures with Delayed Union; A Randomized Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110809007274N19

Enrollment

Registered

2024-10-03

Start date

2024-10-22

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delayed union of long bone fractures. Delayed union of fracture

Interventions

Intervention 1: Intervention group: Patients, in addition to routine treatment including all items (physiotherapy, calcium and vitamin D3 supplements, teriparatide (Cinopar), and non-steroidal anti-in

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Over 18 years old Patients with delayed union (failure to form bone trabeculae and union after 4 months) of long bone fractures (femur, tibia, ulna, and humerus) Patient consent

Exclusion criteria

Exclusion criteria: Pathological fractures Ignored old fractures Old fractures with implant failure Patients with uncontrolled diabetes or liver or kidney disorders Presence of local or systemic infection Patients who are not suitable for autologous donation (thrombocytopenia (less than 100 thousand per microliter) and thrombocytosis (more than 650 thousand per microliter)) Hypofibrogenemia Medicines that affect platelet function, such as corticosteroids, aspirin, vitamin E, green tea Systemic and local infections at the fracture site Smoking

Design outcomes

Primary

Measure	Time frame
Response to treatment (the formation and passage of bone trabeculae at the fracture site in 3 out of 4 cortices is considered a response to treatment.). Timepoint: Before starting work and one month after the third session. Method of measurement: Radiographs will be taken before starting work and one month after the third session to assess the formation of bridging trabeculae in the injured limb.;Duration of union. Timepoint: Before starting work and one month after the third session. Method of measurement: Radiographs will be taken before starting work and one month after the third session to assess the formation of bridging trabeculae in the injured limb.;Infection. Timepoint: Monthly visit. Method of measurement: The presence of infection signs at the injury site, such as pain, erythema, discharge, etc., is noted during the monthly visit.	—

Measure

Time frame

Response to treatment (the formation and passage of bone trabeculae at the fracture site in 3 out of 4 cortices is considered a response to treatment.). Timepoint: Before starting work and one month after the third session. Method of measurement: Radiographs will be taken before starting work and one month after the third session to assess the formation of bridging trabeculae in the injured limb.;Duration of union. Timepoint: Before starting work and one month after the third session. Method of measurement: Radiographs will be taken before starting work and one month after the third session to assess the formation of bridging trabeculae in the injured limb.;Infection. Timepoint: Monthly visit. Method of measurement: The presence of infection signs at the injury site, such as pain, erythema, discharge, etc., is noted during the monthly visit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohsen Mardani-kivi

Rasht University of Medical Sciences

mardani.kivi@gmail.com+98 13 3332 5783

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026