The effect of valproate sodium on treatment of patients with mania

A comparative study: the effect of valproate sodium oral and intravenous loading dose on treatment of patients with acute mania

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201108087260N1

Enrollment

Registered

2011-10-25

Start date

2011-09-14

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bipolarity- mania episode. Manic episode

Interventions

Intervention 1: Control group: 20mg/kg of valproate sodium tablet plus placebo for injection. Intervention 2: Experiment group: 20mg/kg intravenous valproate sodium and placebo as a tablet.

Treatment - Drugs

Control group: 20mg/kg of valproate sodium tablet plus placebo for injection

Experiment group: 20mg/kg intravenous valproate sodium and placebo as a tablet

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients who are in acute mania episode. Exclusion criteria: patients with other psychiatric disorders.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Plasma level. Timepoint: one, three and seven days after injection. Method of measurement: measure of plasma level.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mehdi Sharifmehr

Hamadan university of medical sciences

m.sharifmehr@umsha.ac.ir+98 81 1828 5015

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026