Aphanizomenon Flos-aquae extract effect on mobilization of bone marrow stem cells

Effect of a Aphanizomenon Flos-aquae extract on mobilization of bone marrow stem cells and metabolic profile of patients with type 2 diabetes

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201108074920N2

Enrollment

Registered

2013-07-19

Start date

2013-08-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus. Diabetes Mellitus

Interventions

Intervention 1: Control group: 1 placebo capsule of StemFlo before breakfast and 2 placebo capsules of StemEnhance after dinner for a period of 12 weeks. Intervention 2: AFA (intervention) group: 1 c

Placebo

Treatment - Drugs

Control group: 1 placebo capsule of StemFlo before breakfast and 2 placebo capsules of StemEnhance after dinner for a period of 12 weeks

AFA (intervention) group: 1 capsule of StemFlo before breakfast and 2 capsules StemEnhance after dinner for a period of 12 weeks

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with type 2 diabetes; between 20 to 60 years with HbA1C=7.5% will be included in the study. Exclusion criteria are pregnancy; presence advanced diabetic complications; renal failure or cardiovascular disease; use of vitamin or mineral supplements in the last 2 months before the study; change or introduction of new medications to the treatment of diabetes, and a history of inflammatory illness or cancer.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Stem cell marker of CD34. Timepoint: Before and After treatment (0 and 12 weeks). Method of measurement: Flocytometry method.	—

Secondary

Measure	Time frame
Blood Urea Nitrogen (BUN). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;C-peptide. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;Low Density Lipoprotein (LDL). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Interleukine-6 (IL-6). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;Malon Dialdehyde (MDA). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;SGOT. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;SGPT. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;TNF-a. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;Total Cholestrol. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Triglyceride. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Fasting Blood Sugar. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Creatinine. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;High Density Lipoprotein (HDL). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Glycosylated Hemoglobin (HbA1c). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Chromatography.;Height. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Stadiometer.;Weight. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Digital weight gauge.	—

Measure

Time frame

Blood Urea Nitrogen (BUN). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;C-peptide. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;Low Density Lipoprotein (LDL). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Interleukine-6 (IL-6). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;Malon Dialdehyde (MDA). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;SGOT. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;SGPT. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;TNF-a. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;Total Cholestrol. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Triglyceride. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Fasting Blood Sugar. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Creatinine. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Elisa.;High Density Lipoprotein (HDL). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Enzymatic Calorimetry.;Glycosylated Hemoglobin (HbA1c). Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Chromatography.;Height. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Stadiometer.;Weight. Timepoint: Before and After Treatment (0 and 12 weeks). Method of measurement: Digital weight gauge.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Sanaei

Chronic Diseases Research Center

sanaeimaryam@yahoo.com+98 21 8835 4158

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026