Polycystic ovarian syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Metformin, 500 mg/ bid for three months. Intervention 2: Calcitriol, 0.25 microgram bid for three months. Intervention 3: Placebo, two tablet in day for three months.
Treatment - Drugs
Placebo
Metformin, 500 mg/ bid for three months
Calcitriol, 0.25 microgram bid for three months
Placebo, two tablet in day for three months
Sponsors
Vice chancelor for research, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: Presence of two criteria of these three was necessary: 1 – Anovulation or oligoovulation (or menstrual cycle less than 6 cycles in 12 month) 2 – Clinical or biochemical symptoms of hyperandrogenemia include: acne, hirsutism , alopecia or increased serum androgen levels . 3- View of polycystic ovary with 12 follicles or more in each ovary with diameter between 2-9 mm or increased ovarian volume more than 10 cm3 by ultrasound. For other cause of hyperandrogenism including : congenital adrenal hyperplasia , Cushing's syndrome , hyperprolactinemia, hypothyroidism and tumors that secrete androgens were excluded by laboratory markers.With regard to the check of the 25 hydroxy vitamin D level in patients , we excluded all the patients that had systemic factors that interfere on vitamin D level like : history of renal disease , hepatic disease , malabsorption, alcoholism , breastfeeding , pregnancy and all the people who used drugs that effective on vitamin D level like : anti epileptic agents , supplement of calcium and vitamins and glucocorticoids
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin resistance. Timepoint: 3 months. Method of measurement: Lab data , FBS and insulin level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ovulation. Timepoint: 3 months. Method of measurement: Sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShokoufeh Bonakdaran
Fellowship of endocrinology
Outcome results
None listed