Comparison of the evolution of the effect of the two methods of prescribing the mature substance to the lungs of premature infants: Delicate endotracheal catheter during spontaneous respiration with intratracheal intubation in infants at two years of age

Comparison prognosis the effect of two methods surfactant administration: Minimally invasive surfactant therapy(MIST) versus InSurE (Intubate, surfactant administration and extubate) in preterm neonates with respiratory distress syndrome at two year

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110807007244N8

Enrollment

148

Registered

2022-06-11

Start date

2022-06-07

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory distress syndrome of newborn. Respiratory distress syndrome of newborn

Interventions

Intervention 1: Intervention group: Minimally invasive surfactant therapy(MIST). Intervention 2: Control group: INSURE (Intubation, surfactant administration and extubation)).

Eligibility

Sex/Gender

All

Age

1 Days to 24 Months

Inclusion criteria

Inclusion criteria: Premature infants with respiratory distress syndrome with a gestational age of 26 to 34 weeks require surfactant

Exclusion criteria

Exclusion criteria: Congenital anomaly Requires mechanical ventilation in the delivery room Congenital infection Asphyxia Congenital heart disease History of developmental delay

Design outcomes

Primary

Measure	Time frame
Duration of need for respiratory support. Timepoint: During hospitalization. Method of measurement: Number of days of need for respiratory support.	—

Secondary

Measure	Time frame
Two years development. Timepoint: 24 monthly. Method of measurement: Denver Test 2.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHassan Boskabadi

Mashhad University of Medical Sciences

Boskabadih@mums.ac.ir+98 51 3841 2169

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026