comparison of various combinations of ondansetron ,dexamethson and methoclopramide for prevention of post operative nausea and vomiting

Comparing the preventive effect of variuos combinations of ondansetron,dexamethason and metoclopramide on post operative nausea and vomiting after balanced anesthesia for orthopedic surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201108067093N2

Enrollment

420

Registered

2012-09-26

Start date

2012-05-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: post operative nausea and vomiting. Condition 2: post operatve nausea and vomiting. Glucocorticoids and synthetic analogues Antiallergic and antiemetic drugs

Interventions

Intervention 1: intervention group 1:ondansetron 4mg=4cc,intravenous as stat injection. Intervention 2: Control :placebo =normal saline =4cc ,intravenous as stat injectin. Intervention 3: intervention

Treatment - Drugs

Placebo

intervention group 1:ondansetron 4mg=4cc,intravenous as stat injection

Control :placebo =normal saline =4cc ,intravenous as stat injectin

intervention group 2:metoclopramid 4mg=4cc,intravenous as stat injectin

intervention group 3:dexamethason 4mg=4cc,intravenous as stat injectin

intervention group 4:ondansetron 4mg+metoclopramid 4mg=4cc ,intravenous as stat injectin

intervention group 5: ondansetron 4mg+dexamethason 4mg=4cc,intravenous as stat injectin

intervention group 6: metoclopramid 4mg+dexamethason4mg=4cc,intravenous as stat injectin

Eligibility

Sex/Gender

All

Age

16 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:ASA class 1,2; age 16-65;BMI<30; Candidate for orthopedic surgery Exclusion criteria:Severe sleep apnea syndrome;Significant cardiac,respiratory,hepatic,gastrointestinal or renal disease;Known hypersensitivity to each of study drug;History of post operative nausea and vomiting in previous surgeries;Taking medication with known antivomiting properties; Pregnant or breast feeding mother; Opioid and alcohol addiction;Difficult intubation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Post operative nausea and vomiting. Timepoint: every 8 hours :first measurement:2 hours after discharge from recovery room and every 8 hours thereafter for the next 24 hours. Method of measurement: ponv scale.	—

Secondary

Measure	Time frame
Biochemical laboratory data. Timepoint: once (preoperative). Method of measurement: blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Sabermoghadam

North Khorasan University of Medical Sciences, Bojnurd, Iran

sabermoghadam41@gmail.com+98 58 4229 6965

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026