Preterm labour. Preterm labour
Conditions
Interventions
42 pregnant women with diagnosis of preterm labor will be treated by10 mg nitroglycerine patch that will be applied on abdomen. 1 hour later vaginal exam will be done and uterine contractions will be
42 pregnant women with diagnosis of preterm labor will be treated by placebo patch that will be applied on abdomen. 1 hour later vaginal exam will be done and uterine contractions will be assessed the
Treatment - Drugs
Placebo
Intervention group
Control group
Sponsors
Vice Chancellor for research, Kermanshah University of Medical Sciences.
Eligibility
Sex/Gender
Female
Age
15 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 15 _45 years singleton pregnant women; GA 27_ 35 weeks with painful uterine contractions; equal or more than 4 contractions per 20 min or bishop score equal or more than 3. Exclusion criteria: maternal or fetal indication for termination of pregnancy; multiple gestation; premature rupture of membrane; fetal anomaly; cervical dilatation equal or more than 5 cm; sensitivity to nitrates or nitrates contraindications; chorioamnionitis (maternal fever ,leukocytosis, fetal tachycardia); maternal heart disease; Vasa previa; Placenta previa; vaginal bleeding except bloody show.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delivery. Timepoint: 24& 48 hour. Method of measurement: Delivery is don or delivery is not done. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure. Timepoint: At randomization and 1 h, 24 h& 48 h later. Method of measurement: mmHg.;Maternal heart rate. Timepoint: At randomization and 1 h, 24 h& 48 h later. Method of measurement: Beat/min.;Number of doses of corticosteroid . Timepoint: At randomization and24 h after randomization. Method of measurement: Number.;Fetal heart rate. Timepoint: At randomization and one hour later. Method of measurement: Beat/min.;Incidence of complication (headache, vertigo, nausea, vomiting, skin redness, hypo tension). Timepoint: From randomization till 48 h later. Method of measurement: it is done or it is not done (patient complaint: headache, vertigo, nausea, vomiting or measured by investigator: skin redness, hypo tension).;Change in cervical dilatation. Timepoint: At randomization and 1 h, 24 h& 48 h later. Method of measurement: cm. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParnian Kord Jamshidi
Kermanshah University of Medical Sciences.
Outcome results
None listed