Genetic screening of embryos produced by ICSI method to reduce the possible incidence of celiac disease in the next generation

Launching pre-implantation genetic screening in families with celiac disease to reduce the risk of celiac disease in the next generation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110804007223N12

Enrollment

Registered

2023-10-28

Start date

2023-10-23

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Celiac. Celiac disease

Interventions

Intervention 1: Intervention group: Using the ICSI-assisted treatment method to create in vitro embryo, and the PGS method for genetic screening of the produced embryos. Intervention 2: Control group:

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The satisfaction of the couples with participation in the study Celiac disease confirmed through laboratory tests and/or endoscopy

Exclusion criteria

Exclusion criteria: Infertility prevention due to systemic diseases or medication use. History of any type of cancer.

Design outcomes

Primary

Measure	Time frame
Reducing the genetic chance of celiac disease in the next generation. Timepoint: time of birth. Method of measurement: Genetic assessment of HLA-DQ typing and HLA DR3-DQ2/DR4-DQ8 genotype.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hossein Nasr-Esfahani

Iranian academic center for education culture and research

nasr.royan@gmail.com+98 31 9501 5680

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026