Effect of Alpha-Lipoic Acid on sperm parameters in varicocele individuals

The effect of Alpha-Lipoic Acid on sperm parameters, sperm chromatin and oxidative stress in infertile men after varicocelectomy: a double-blind controlled randomized trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110804007223N10

Enrollment

Registered

2019-12-22

Start date

2019-08-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male factor infertility. Male infertility

Interventions

Intervention 1: Intervention group: After varicocelectomy surgery (microsurgical), administration of alpha-alipoic acid at a dose of 600 mg (one capsule daily) for 80 days. This drug is purchased from

Eligibility

Sex/Gender

Male

Age

24 Years to 46 Years

Inclusion criteria

Inclusion criteria: Male gender Primary infertility Presence of left-sided varicocele (grades II and III) as diagnosed by palpation and Doppler duplex ultrasound

Exclusion criteria

Exclusion criteria: Azoospermic men Leukocytospermic men

Design outcomes

Primary

Measure	Time frame
Sperm parameters (concentration, motility, and morphology). Timepoint: Before and 80 days after varicocelectomy surgery. Method of measurement: Light microscope.;DNA integrity. Timepoint: Before and 80 days after varicocelectomy surgery. Method of measurement: fluorescent microscope, flow cytometry.;Protamine deficiency. Timepoint: Before and 80 days after varicocelectomy surgery. Method of measurement: fluorescent microscope.;Lipid peroxidation. Timepoint: Before and 80 days after varicocelectomy surgery. Method of measurement: flow cytometry.	—

Measure

Time frame

Sperm parameters (concentration, motility, and morphology). Timepoint: Before and 80 days after varicocelectomy surgery. Method of measurement: Light microscope.;DNA integrity. Timepoint: Before and 80 days after varicocelectomy surgery. Method of measurement: fluorescent microscope, flow cytometry.;Protamine deficiency. Timepoint: Before and 80 days after varicocelectomy surgery. Method of measurement: fluorescent microscope.;Lipid peroxidation. Timepoint: Before and 80 days after varicocelectomy surgery. Method of measurement: flow cytometry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hossein Nasr-Esfahani

Iranian academic center for education culture and research

nasr.royan@gmail.com+98 31 9501 5682

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026