Traditional medical treatment versus interventional approach in acute iliofemoral vein thrombosis

Comparing the effect of conventional therapy (Heparin followed by warfarin) with imterventional therapy (thrombolysis with or without angioplasty and stenting) on venous patency in patients who admitted with acute iliofemoral DVT in Tehran Heart Center emergency department

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201108035625N3

Enrollment

Registered

2011-08-13

Start date

2011-08-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute liofemoral veins thrombosis. other venous embolism and thrombosis

Interventions

Intervention 1: Intervention: lytic therapy will be achieved by placing a catheter in the contralateral femoral vein, the right internal jugular vein, or the ipsilateral popliteal vein for direct intr

Treatment - Drugs

Intervention: lytic therapy will be achieved by placing a catheter in the contralateral femoral vein, the right internal jugular vein, or the ipsilateral popliteal vein for direct intra-clot infusion.

Control: conventional treatment will consist of intravenous heparin followed by warfarin. A loading dose of 5,000 to 10,000 units heparin followed by 1,000 to 2,000 units per hour will be given by con

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Consecutive patients with acute extensive iliofemoral venous thrombosis will be included. Exclusion criteria: previous history of allergy to thrombolytic or contrast agents; anticoagulation contrandications; bleeding disorders, active internal bleeding, recent gastrointestinal bleeding, recent cerebrovascular accident, recent major surgery (<10 days), recent serious trauma, severe hypertension, pregnancy or recent delivery, metastatic malignancy with central nervous system involvement, chronic iliofemoral venous thrombosis (more than 14 days from incidence);patients with survival of less than 1 year; severe renal failure (GFR<30); history of subarachnoid hemorrhage (SAH) or intra cranial hemorrhage (ICH)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Venous patency. Timepoint: One, six and twelve months follow up. Method of measurement: Doppler ultra sonography and MDCT venography.	—

Secondary

Measure	Time frame
Symptom changes (pain,edema,varices,...). Timepoint: One, six and twelve months follow up. Method of measurement: Clinical evaluation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Neda Ghaffari-Marandi

Tehran Heart Center

ghaffari_15255@yahoo.com+98 21 8802 9600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026