Buerger`s disease. Thromboangiitis obliterans [Buerger]
Conditions
Interventions
Intervention 1: Intervention group will take tab. Folic acid 5 mg per day, for 6 month. Intervention 2: Control group will take placebo(the same color, size, box to tab Folic acid 5 mg) one tablet per
Treatment - Drugs
Placebo
Intervention group will take tab. Folic acid 5 mg per day, for 6 month
Control group will take placebo(the same color, size, box to tab Folic acid 5 mg) one tablet per day for 6 month
Sponsors
Applied Physiology Research Center
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Inclusion criteria: Buerger`s patients referring to Alzahra hospital who have consent of participation to study; history of smoking; onset of disease before 50 year-old; upper limb involvement or phlebitis migrants; obliterative arterial disease below popliteal artery and no risk factor of atherosclerosis except smoking; no history of hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular disease or collagen vascular disease. Exclusion criteria: surgical (sympathectomy or vascular bypass) or medical (Illeoprost or corticosteroid) changes in treatment; starting Aspirin, calcium channel blocker, VitB6 or VitB12 or stop smoking during the study; drug incompliance during the study and not willing to continue the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scale of wound. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Wagner Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Homocysteine. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Lab test.;Scale of pain. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: VAS.;Anticardiolipin. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Lab test.;Size of wound. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Millimeter.;Number of steps walkingwithout pain. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Number.;Sense of patient about healing. Timepoint: At the 2nd and 6th months. Method of measurement: Ask a patient.;Minor amputation. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Number.;Major amputation. Timepoint: At the beginnig and 2nd and 6th months. Method of measurement: Number. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfrooz Eshaghian
Applied Physiology Research Center
Outcome results
None listed