Poor Ovarian Response. Complications associated with artificial fertilization
Conditions
Interventions
Intervention 1: Intervention group: Early antagonist protocol: Recombinant FSH (150-225 IU) and GnRH Antagonist (Cetrotid 0.25 mg) will be started simultaneously on the second day of the cycle. Final
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 44 Years
Inclusion criteria
Inclusion criteria: Age between 18 up to 44 years History of poor ovarian response (POR) in previous cycle (oocyte less than 3 in a conventional protocol) Antral follicle count (AFC) less than 5-7 or Anti-Müllerian hormone (AMH) <0.5-1.1 Poor ovarian response after maximal stimulation
Exclusion criteria
Exclusion criteria: Polycystic Ovarian Syndrome Hypothalamic amenorrhea Uterine congenital anomalies and uterine cavity abnormalities (Bicorn uterus, Unicorn uterus, Asherman, Liomyuma, Polyp, etc.) Repeated IVF failure (more than three consecutive failures)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Mature Retrieved Oocytes. Timepoint: At the end of the study. Method of measurement: Embryology Report.;Embryos. Timepoint: At the end of the study. Method of measurement: Embryology Report.;Total Gonadotropins used. Timepoint: At the end of the study. Method of measurement: Checklist.;Total Antagonist used. Timepoint: At the end of the study. Method of measurement: Checklist.;Total Days of Induction of ovulation. Timepoint: At the end of the study. Method of measurement: Checklist.;Total Number of Retrieved Oocytes. Timepoint: At the end of the study. Method of measurement: Embryology Report. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Pregnancy. Timepoint: At the end of the study. Method of measurement: Pregnancy confirmed by both high levels of hCG and presence of gestational sac with positive heart beats in ultrasound.;Ongoing pregnancy. Timepoint: At the end of the study. Method of measurement: Pregnancy had continued more than 12 weeks of gestation.;Chemical Pregnancy. Timepoint: At the end of the study. Method of measurement: A very early pregnancy loss in the first few weeks.;Luteinizing Hormone (LH) Level. Timepoint: In the second day of the cycle and then one time in trigger day. Method of measurement: Blood Test.;Progestrone Level. Timepoint: In the second day of the cycle and then one time in trigger day. Method of measurement: Blood Test.;Estradiol Level. Timepoint: In the second day of the cycle and then one time in trigger day. Method of measurement: Blood Test.;Implantation Rate. Timepoint: At the end of the study. Method of measurement: The percentage of embryos which successfully undergo implantation compared to the number of embryos transferred in a given period.;Fertilization rate. Timepoint: At the end of the study. Method of measurement: Percentage of transformation of micro injected oocytes into two pronuclei. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Tayebeh Esfidani
Tehran University of Medical Sciences
Outcome results
None listed