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repeated gonadotropin-releasing hormone agonist (GnRH-a) versus low dose human chorionic gonadotropin (HCG)

Comparison of the efficacy of repeated gonadotropin-releasing hormone agonist (GnRH-a) versus adding low dose human chorionic gonadotropin (HCG) for ovulation induction in patients with polycystic ovary syndrome undergoing IVF/ICSI

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20110731007165N8
Enrollment
60
Registered
2019-12-19
Start date
2019-12-31
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility associated with polycystic ovarian syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: First Intervention group (Group A): Subcutaneous injection of 0.2mg Decapeptyl ampoule (GnRH-a) that will be repeated with a half-dose after 12 hr. Intervention 2: Second Intervention

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 38 Years

Inclusion criteria

Inclusion criteria: Aged between 18-38 years old Body mass index below 30 and above 19 kg/m2 Normal uterine cavity Ovulation induction by GnRH antagonist cycle regimen

Exclusion criteria

Exclusion criteria: Repeated implantation failure WHO 1 group Using Percutaneous Epididymal Sperm Aspiration (PESA) or testicular sperm extraction (TESE) History of taking oral contraceptive pills for more than three months before the IVF Endocrinopathies

Design outcomes

Primary

MeasureTime frame
Ovarian hyperstimulation syndrome (OHSS). Timepoint: At the end of the study. Method of measurement: Hospital records.;Metaphase II (MII) oocytes. Timepoint: At the end of the study. Method of measurement: Hospital records.;Total Number of oocytes. Timepoint: At the end of the study. Method of measurement: Hospital records.;Number of embryos. Timepoint: At the end of the study. Method of measurement: Hospital records.

Secondary

MeasureTime frame
Endometrial thickness. Timepoint: At the time of embryo transfer. Method of measurement: Vaginal Ultrasound.;Embryos quality. Timepoint: At the end of the study. Method of measurement: Hospital records.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahdiyeh Sadat Portabatabaei

Arash Women 's Hospital

prtbtbaeim@gmail.com+98 21 7771 9922

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026