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Effect of Sodium Valproate on Adenomyosis

Assessment of Effect of Sodium Valproate on Adenomyosis patients attending to Gynecology Clinic of Arash Women's Hospital

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20110731007165N6
Enrollment
42
Registered
2019-09-09
Start date
2018-11-22
Completion date
Unknown
Last updated
2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenomyosis. Endometriosis of uterus

Interventions

Intervention 1: Intervention group: The Depakin oral tablets will be started at a dose of 500 mg twice a day from the 5th day of the menstrual cycle in the first week. The dosage will be increased to

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Having clinical symptoms of adenomyosis (chronic pelvic pain, Heavy Menorrhagia, abnormal uterine bleeding, acute Dysmenorrhea, Dyspareunia, enlargement of the uterus, tenderness of the uterus) Pelvic examination suggestive of Adenomyosis Transvaginal ultrasound diagnostic findings of Adenomyosis

Exclusion criteria

Exclusion criteria: Pregnancy, suspicion of pregnancy or planning to become pregnant Breastfeeding Hepatic, renal, heart and internal diseases Lack of patient collaboration or desire to performing the hysterectomy

Design outcomes

Primary

MeasureTime frame
Dysmenorrhea. Timepoint: At the beginning of the study (before the intervention) and 1, 2, 3, 4, 5 and 6 months after starting the intervention. Method of measurement: Visual Analogue Scale.;Uterine Size. Timepoint: At the beginning of the study (before the intervention) and 6 months after starting the intervention. Method of measurement: Ultrasound.;The statues of the palpable nodule in the vaginal examination. Timepoint: At the beginning of the study (before the intervention) and 1, 2, 3, 4, 5 and 6 months after starting the intervention. Method of measurement: Vaginal Examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Rosita Firoozian

Arash Women 's Hospital

rosita_firouziyan@yahoo.com+98 21 7771 9922

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026