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Use of probiotics to prevent diarrhea caused by antibiotics

Evaluation of the effect of probiotic Lactobacillus to prevent diarrhea caused by antibiotics

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201107166056N2
Enrollment
300
Registered
2011-09-22
Start date
2011-02-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diarrhoea. Functional diarrhoea

Interventions

Intervention 1: Case group will receive two tablets solution containing 150 million spores of Lactobacillus by oral gavage every 12 hours, simultaneously with antibiotics. Intervention 2: 100 grams of
Treatment - Drugs
Placebo
Case group will receive two tablets solution containing 150 million spores of Lactobacillus by oral gavage every 12 hours, simultaneously with antibiotics.
100 grams of lactose-free milk will gavage two times a day for control group.

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients who need to receive antibiotics during hospitalization. Exclusion criteria: Patients initially admitted with diarrhea. patients taking antibiotics 4 weeks before admission. Patients with neutropenia. Patients who had bowel surgery. Patients who have artificial heart valves, or endocarditis.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Diarrhea. Timepoint: at the start of the study, in the course of antibiotic therapy and completion of antibiotic treatment. Method of measurement: Clinical evaluation.

Secondary

MeasureTime frame
Colitis. Timepoint: at the start of the study, in the course of antibiotic therapy and completion of antibiotic treatment. Method of measurement: Clinical evaluation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Nader Zarinfar

Arak University of Medical Sciences

zarinfar@arakmu.ac.ir+98 86 1224 1411

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026