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Comparison of letrozole and clomiphen in mild protocol among infertile poor responders

Comparison of letrozole and clomiphen in mild protocol among infertile poor responders

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201107146420N3
Enrollment
200
Registered
2011-08-10
Start date
2009-01-01
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Inflammatory diseases of female pelvic organs

Interventions

Intervention 1: group I: clomiphen citrate 50 mg twice a day from 3th day of menstruation cycle until 7th day of the cycle. Intervention 2: group II: letrozole 2.5 mg twice a day from 3th of the cyc

Sponsors

shahid sadoughi university of medical science
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: three or fewer oocytes were been retrieved in previous failed ART cycle; serum E2 levels = 500 pg/ml on the day of hCG administration.

Exclusion criteria

Exclusion criteria: BMI >30 mg/m2; endocrine or metabolic disorders; history of ovarian surgery; severe endometriosis; azoospermia in male partner. FSH >15 m IU/ml

Design outcomes

Primary

MeasureTime frame
Chemical pregnancy. Timepoint: 12 day after embryo transfer. Method of measurement: beta hCG blood test.;Clinical pregnancy. Timepoint: 3 weeks after chemical pregnancy. Method of measurement: observation of fetal heart activity by transvaginal ultrasonography.;Implantation rate. Timepoint: 3 weeks after chemical pregnancy. Method of measurement: the ratio of the number of embryonic sacs diagnosed by sonography to the total number of the embryos transferred.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Eftekhar

Research and Clinical Center for Infertility

eftekhar@ssu.ac.ir+98 35 1824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026