Migraine. Migraine
Conditions
Interventions
Intervention 1: in negative balance of iron group will receive 400 mg/day valproate Na in all periods (45 days each period) and iron sulfate (50mg/day) in second period of the study. Intervention 2: i
Treatment - Drugs
in negative balance of iron group will receive 400 mg/day valproate Na in all periods (45 days each period) and iron sulfate (50mg/day) in second period of the study.
in iron deficiency anemia group will receive 400 mg/day valproate Na in all periods (45 days each period) and iron sulfate (50mg/day) in second period of the study.
in normal level of iron group will receive 400 mg/day valproate Na in all periods (45 days each period) and iron sulfate (50mg/day) in second period of the study.
Sponsors
Vice chancellor for research, Shahrekord University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
15 Years to 45 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: ?Female Patients having migraine; age between 15 to 45 years; the first group with negative balance of iron; the second group with iron deficiency; third group with normal level of iron. (Patients with the following characters will be considered as iron deficiency (MCHC360µg/dl, MCH<27pg/d,Hb<10g/dl, HCT). Patients with feritin less than 20 microgram in liter will be considered as negative balance of iron.) Exclusion criteria: Pregnancy, lactation, using psychiatric, OTC or other sexual hormones, having systemic illness such as hypertension, asthma.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of headache attacks. Timepoint: three periods of 15 days. Method of measurement: questionnaire.;Severity of headache attacks. Timepoint: three periods of 15 days. Method of measurement: questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ferritin. Timepoint: At the beginning and at the end of the study. Method of measurement: Laboratory methods.;Blood iron. Timepoint: At the beginning and at the end of the study. Method of measurement: laboratory methods. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahmoud Rafieian
SHahrekord University of Medical Sciences
Outcome results
None listed