5-fluorouracil induced oral mucositis. Disease of oral cavity : stomatitis
Conditions
Interventions
Intervention 1: Sucralfate , mouthwash , 15 percent , four times a day for a week. Intervention 2: Placebo mouthwash , 4 times a day for a week. Intervention 3: Sucralfate 15 percent mouth wash plus s
Prevention
Placebo
Treatment - Drugs
Sucralfate , mouthwash , 15 percent , four times a day for a week
Placebo mouthwash , 4 times a day for a week
Sucralfate 15 percent mouth wash plus syrup Hydroxyzine , four times a day until oral wound healing
Syrup Hydroxyzine plus placebo , four times a day until oral wound healing
Sponsors
Vice chancellor for research, Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:Cancer patients between 18-70 years receiving 5-fluorouracil containing chemotherapy regimens. Exclusion criteria: Sucralfate intolerance or inappropriate use of the mouth wash
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mouth sores. Timepoint: every 3 days. Method of measurement: Use of the WHO table and ruler. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: Before and after 1 months of intervention. Method of measurement: Visual analoug scale (VAS).;Dysphagia to liquids. Timepoint: Before and after 2 months of intervention. Method of measurement: Ask a question.;Dysphagia to solids. Timepoint: weekly. Method of measurement: Ask a question.;Bleeding. Timepoint: Before and after 2 months of intervention. Method of measurement: Ask a question. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Azhdari
Vice chancellor for research, Mazandaran University of Medical Sciences
Outcome results
None listed