Evaluation of anti-emetic efficacy of Aprepitant in patients undergo hematopoitic stem cell transplantation in a teaching hospital

Evaluation of anti-emetic efficacy of Aprepitant in patients undergo hematopoitic stem cell transplantation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201107026930N1

Enrollment

Registered

2012-08-14

Start date

2012-05-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Autologous bone marrow transplantation. Condition 2: emesis. Other transplanted organ and tissue status Haematemesis

Interventions

Intervention 1: Intervention group: dexamethasone 8 mg IV daily Grarisetron1.5 mg bid IV Aprepitnt slow infusion (120 mg first day - the second and third days of 80 mg ( po). Intervention 2: Control G

Treatment - Drugs

Intervention group: dexamethasone 8 mg IV daily Grarisetron1.5 mg bid IV Aprepitnt slow infusion (120 mg first day - the second and third days of 80 mg ( po)

Control Group: Granisetron 1.5 mg bid IV dexamethasone 8 mg IV daily,

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients who undergo autologus bone marrow transplantation. Exclusion criteria: severe hepatic and renal failure during drug administration; hypersensitivity to the drug.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The patient's nutritional status. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;The need for tpn. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Recorded in the file.;Number of vomiting. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient - the nurse reported.;Nausea. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.	—

Measure

Time frame

The patient's nutritional status. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;The need for tpn. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Recorded in the file.;Number of vomiting. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient - the nurse reported.;Nausea. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.

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Secondary

Measure	Time frame
Constipation. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;The number of cases disposed. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Headache. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Diarrhea. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Fever. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: By Digital Thermometers.;Hiccup. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Anorexia. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Seizure. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Mucositis. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Examination.;Alkaline phosphatase levels. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;Amylase levels. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;The rate of bilirubin. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;Transaminase levels. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;Blood glucose. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;Creatinine levels. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measuremen	—

Measure

Time frame

Constipation. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;The number of cases disposed. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Headache. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Diarrhea. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Fever. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: By Digital Thermometers.;Hiccup. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Anorexia. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Seizure. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Ask the patient.;Mucositis. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Examination.;Alkaline phosphatase levels. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;Amylase levels. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;The rate of bilirubin. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;Transaminase levels. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;Blood glucose. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measurement.;Creatinine levels. Timepoint: 5 days prior to the intervention until after patient discharge. Method of measurement: Laboratory measuremen

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahshid Mehdizadeh

Shahid Beheshti university of medical scinces

mahshid_mehdizadeh@yahoo.com+98 21 2303 1499

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026