Comparison of treatment outcomes between letrozole with Gonadotropins in Polycystic Ovarian Syndrome patients

Comparing the treatment outcomes between letrozole and Clomiphene citrate (CC) combined with Gonadotropins in CC resistant Polycystic Ovarian Syndrome (PCOS) patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201106271233N2

Enrollment

130

Registered

2011-07-30

Start date

2011-09-12

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disorders of other endocrine glands. Polycystic ovarian syndrome

Interventions

Intervention 1: Clomiphene citrate is started from day 3 to 7 then Gonal F 75IU/day is used from 7th day of menstrual cycle. Intervention 2: Letrozol is started from day 3 to 7 then Gonal F 75IU/day i

Treatment - Drugs

Clomiphene citrate is started from day 3 to 7 then Gonal F 75IU/day is used from 7th day of menstrual cycle

Letrozol is started from day 3 to 7 then Gonal F 75IU/day is used from 7th day of menstrual cycle

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: having PCOS according to Rotterdam criteria and, infertility for one year, age 20-39 years old Exclusion criteria: tubal obstruction, infertility with male factor, hypersensitivity to Clomiphene Citrate or letrozole, presence of diabetes, thyroid or kidney disease, ovarian drilling, ovarian cyst on day 3 of menstrual cycle

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Endometrial thickness. Timepoint: Every 2-3 days. Method of measurement: Transvaginal ultrasonography.	—

Secondary

Measure	Time frame
Follicles greater than 16mm. Timepoint: Every 2-3 days. Method of measurement: Transvaginal sonography.;Clinical pregnancy. Timepoint: 14days after IUI. Method of measurement: Ultrasonography two weeks after positive BHCG for finding gestetaional sac.;Chemical pregnancy. Timepoint: 14days after IUI. Method of measurement: bHCG measurment.;E2 level. Timepoint: Once in a cycle. Method of measurement: On the day of HCG injection by blood sampling.;Cancellation rate. Timepoint: Every 2-3 days. Method of measurement: Transvaginal sonograhy.;The number of Gonadotropines used. Timepoint: at the end of the cycle. Method of measurement: Number of Ampoules.	—

Measure

Time frame

Follicles greater than 16mm. Timepoint: Every 2-3 days. Method of measurement: Transvaginal sonography.;Clinical pregnancy. Timepoint: 14days after IUI. Method of measurement: Ultrasonography two weeks after positive BHCG for finding gestetaional sac.;Chemical pregnancy. Timepoint: 14days after IUI. Method of measurement: bHCG measurment.;E2 level. Timepoint: Once in a cycle. Method of measurement: On the day of HCG injection by blood sampling.;Cancellation rate. Timepoint: Every 2-3 days. Method of measurement: Transvaginal sonograhy.;The number of Gonadotropines used. Timepoint: at the end of the cycle. Method of measurement: Number of Ampoules.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Asgharnia

Giulan University of Medical Sciences

maryamasgharnia@yahoo.comh_fertility@gums.ac.ir+98 13 1322 5624

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026