infertility. Female infertility
Conditions
Interventions
Intervention 1: First group: Metformin will be started at 500mg daily and increased to maximum dose of 1500 mg daily during 3 weeks. Intervention 2: Second group: clomiphene citrate 100 mg orally for
Treatment - Drugs
First group: Metformin will be started at 500mg daily and increased to maximum dose of 1500 mg daily during 3 weeks.
Second group: clomiphene citrate 100 mg orally for 5 days since 3rd day of menstruation cycle.
Sponsors
Vice chancellor for research, Bushehr University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Infertile anovulating PCO women in reproductive age of 18-30 and BMI of 19-25. Exclusion criteria: Any abnormality in thyroid and prolactin tests; structural abnormalities of uterus and tubes; metabolic disorders; cardiac and liver disease; cushing disease and OCP users.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy. Timepoint: 14 days after ovulation. Method of measurement: ßhCG Test.;Adequate follicle (16-22mm). Timepoint: 13th - 14th day of mensturation cycle. Method of measurement: Vaginal sonography.;Serum progestron level. Timepoint: The 21th day of mensturation cycle. Method of measurement: Biochemical methods for measuring progestron titer.;Alive fetus. Timepoint: The 7th week of pregnancy. Method of measurement: Vaginal sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Multiple pregnancy. Timepoint: 7th week. Method of measurement: Ultasonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr shahnaz Ahmadi
Bushehr University of Medical Sciences, Medical Faculty
Outcome results
None listed