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Comparison of Ondansetron and Dexamethasone in prevention of nausea and vomiting

Comparison of preoperative Ondansetron and Dexamethasone in prevention of postoperative nausea and vomiting after middle ear surgeries

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201106154005N4
Enrollment
219
Registered
2011-07-04
Start date
2009-04-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and vomiting. Nausea and vomiting

Interventions

Intervention 1: Before induction of anesthesia, 4 mg of Ondansetron, will be administered intravenously to Ondansetron group respectively. The volume of the drug prescribed will be 3 mL. Premedication
Treatment - Drugs
Before induction of anesthesia, 4 mg of Ondansetron, will be administered intravenously to Ondansetron group respectively. The volume of the drug prescribed will be 3 mL. Premedication will given usin
Before induction of anesthesia, 8 mg of Dexamethasone will be administered intravenously to Dexamethasone group, respectively. The volume of the drug prescribed will be 3 mL in group. Premedication wi
Before induction of anesthesia, distilled water will be administered intravenously to placebo group, respectively. The volume of the drug prescribed will be 3 mL in group. Premedication will given us

Sponsors

Vice chancellor for research,Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients undergoing ear surgical operations with physical conditions of ASA I or II; Exclusion criteria: Patients with digestive problems, or with a history of treatment with antiemetics and nausea in the last 24 hours and also sever obese patients

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Nausea. Timepoint: 16-24 hours after operation 8-16 hours after operation 2-8 hours after operation 0-2 hours after operation. Method of measurement: questionnaire.;Vomiting. Timepoint: 16-24 hours after operation 8-16 hours after operation 2-8 hours after operation 0-2 hours after operation. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026