Comparison of the effects of intramuscular methylergonovine, intravascular oxytocin, and sublingual prostaglandin in prevention of post partum hemorrhage

Comparison of the effects of intramuscular methylergonovine, intravascular oxytocin, and sublingual prostaglandin (misoprostol) in active management of the third stage of labor

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201106143756N2

Enrollment

150

Registered

2011-09-20

Start date

2010-11-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post partum haemorrhage. Other immediate postpartum haemorrhage

Interventions

Intervention 1: After delivery of anterior shoulder 0.2mg metergin IM,single dose. Intervention 2: After delivery of the anterior shoulder 20 unit oxytocin iv infusion,single dose. Intervention 3: Aft

Prevention

After delivery of anterior shoulder 0.2mg metergin IM,single dose

After delivery of the anterior shoulder 20 unit oxytocin iv infusion,single dose

After delivery of anterior shoulder 400 microgram misoprostole sublingual,single dose

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: women with singleton pregnancy; low risk pregnancies;live fetuses; cephalic presentation; normal blood pressure;no history of postpartum haemorrhage;no history of coagulation disorders;no history of heart disease;no history of seizure; no sever anemia(Hb less than 7) exclusion criteria: uterine atonia ;large lacerations with massive bleeding

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Volume of Postpartum haemorrhage. Timepoint: One hour after delivery. Method of measurement: Scaled container and scaling of the pad in mililiter.;Amount of hemoglobin drop. Timepoint: 24 houres after delivery. Method of measurement: Check of hemoglobin.;Duration of the third phase of parturation. Timepoint: From fetus delivery to expression of placenta. Method of measurement: Check of the time in second.	—

Measure

Time frame

Volume of Postpartum haemorrhage. Timepoint: One hour after delivery. Method of measurement: Scaled container and scaling of the pad in mililiter.;Amount of hemoglobin drop. Timepoint: 24 houres after delivery. Method of measurement: Check of hemoglobin.;Duration of the third phase of parturation. Timepoint: From fetus delivery to expression of placenta. Method of measurement: Check of the time in second.

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Secondary

Measure	Time frame
Nausia , vomitting, diarrhia and fever due to misoprostole. Timepoint: 1 and 2 hour after delivery. Method of measurement: Patient's symptoms and vital siqns.;Hypotension and water intoxication. Timepoint: 1 and 2 hour after delivery. Method of measurement: Patient's symptoms and vital siqns.;Transient hypertension due to metergin. Timepoint: 1 and 2 hour after delivery. Method of measurement: Patient's symptoms and vital siqns.	—

Measure

Time frame

Nausia , vomitting, diarrhia and fever due to misoprostole. Timepoint: 1 and 2 hour after delivery. Method of measurement: Patient's symptoms and vital siqns.;Hypotension and water intoxication. Timepoint: 1 and 2 hour after delivery. Method of measurement: Patient's symptoms and vital siqns.;Transient hypertension due to metergin. Timepoint: 1 and 2 hour after delivery. Method of measurement: Patient's symptoms and vital siqns.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Shahbazian

Ahvaz University of Medical Scienses

shahbazian449@yahoo.com+98 61 1222 2114

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026