The effect of alpha-lipoic acid supplementation on hs-CRP, interleukin-6, body weight and hypertention in male patients with chronic spinal cord injury

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201106122602N6

Enrollment

Registered

2012-05-06

Start date

2012-05-09

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic spinal cord injery. Injury of spinal cord, level unspecified

Interventions

Intervention 1: alpha- lipoic acid, capsule 600 mg, once a day for 12 weeks. Intervention 2: placebo, 6oo mg capsule, once a day for 12 weeks.

Treatment - Drugs

Placebo

alpha- lipoic acid, capsule 600 mg, once a day for 12 weeks

placebo, 6oo mg capsule, once a day for 12 weeks

Eligibility

Sex/Gender

Male

Age

30 Years to 50 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: male; spinal cord injury for at least a year and the maximum is 10 years past the onset of disease; BMI>=18.5; Complete spinal cord injury (lack of motor function below the lesion); age between 30-50 years; informed consent; Lack of specific diseases and malignancies such as liver disease; kidney disease and cancer; Exclusion criteria: no Collaboration; Failure to follow the program of receiving supplements (less than 80%); changes in food pattern ; certain diseases and malignancies during study; Use of antioxidant supplements of at least one month prior to study entry and during study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hs-CRP. Timepoint: Before and after intervention. Method of measurement: ELISA.;IL-6. Timepoint: Before and after intervention. Method of measurement: ELISA.;Weight. Timepoint: Before and after intervention. Method of measurement: Wheelchair scales.;Waist circumference. Timepoint: Before and after intervention. Method of measurement: Meter.;Systolic blood pressure. Timepoint: Before and after intervention. Method of measurement: Mercury barometer.;Diastolic blood pressure. Timepoint: Before and after intervention. Method of measurement: Mercury barometer.;FBS. Timepoint: Before and after intervention. Method of measurement: Colorimetric autoanalyzer.;Energy intake. Timepoint: Before and after intervention. Method of measurement: recall.;Carbohydrates intake. Timepoint: Before and after intervention. Method of measurement: recall.;Protein intake. Timepoint: Before and after intervention. Method of measurement: recall.;Fat intake. Timepoint: Before and after intervention. Method of measurement: recall.;BMI. Timepoint: Before and after intervention. Method of measurement: mathematics.	—

Measure

Time frame

Hs-CRP. Timepoint: Before and after intervention. Method of measurement: ELISA.;IL-6. Timepoint: Before and after intervention. Method of measurement: ELISA.;Weight. Timepoint: Before and after intervention. Method of measurement: Wheelchair scales.;Waist circumference. Timepoint: Before and after intervention. Method of measurement: Meter.;Systolic blood pressure. Timepoint: Before and after intervention. Method of measurement: Mercury barometer.;Diastolic blood pressure. Timepoint: Before and after intervention. Method of measurement: Mercury barometer.;FBS. Timepoint: Before and after intervention. Method of measurement: Colorimetric autoanalyzer.;Energy intake. Timepoint: Before and after intervention. Method of measurement: recall.;Carbohydrates intake. Timepoint: Before and after intervention. Method of measurement: recall.;Protein intake. Timepoint: Before and after intervention. Method of measurement: recall.;Fat intake. Timepoint: Before and after intervention. Method of measurement: recall.;BMI. Timepoint: Before and after intervention. Method of measurement: mathematics.

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Secondary

Measure	Time frame
Vitamin C. Timepoint: before and after intervention. Method of measurement: recall.;Vitamin E. Timepoint: before and after intervention. Method of measurement: recall.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactVida Mohammadi

Tehran University of Medical Sciences

mohammadi_vida@yahoo.com+98 21 8877 9118

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026