radiotherapy-induced oral mucositis. Other and unspecified lesions of oral mucosa
Conditions
Interventions
Intervention 1: control : placebo cap. , 3times a day, 66days. Intervention 2: intervention : zinc sulfate cap. containing 30mg zinc , 3times a day, 66days.
Placebo
Treatment - Drugs
control : placebo cap. , 3times a day, 66days
intervention : zinc sulfate cap. containing 30mg zinc , 3times a day, 66days
Sponsors
Vice chancellor for research, Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 149 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Minimum accumulative dose of 40 Gy according to treatment protocol; Complete exposure of oral field to x ray; Minimum age of 18; Exclusion criteria were: history of previous radiotherapy of the head neck or cytotoxic chemotherapy; Pregnancy; Preexisting oral conditions; Use of other medications related to oral mucositis during study period; Any systemic diseases interfering with healing; interruption of radiotherapy
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Erythema. Timepoint: before intervention, until the end of intervention (weekly, 8weeks). Method of measurement: according to OMAS (mild,severe).;Ulceration. Timepoint: before intervention, until the end of intervention (weekly, 8weeks). Method of measurement: according to OMAS(milimeter). | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: every week. Method of measurement: oral examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNeda Babaee
Babol university of medical sciences
Outcome results
None listed