Condition 1: Infertility. Condition 2: Endometriomas. ???????? ????? ????????????????????
Conditions
Interventions
Intervention 1: First group receives 3 consecutive single IM doses of Dipherelin 3.75mg (Beaufouipfen, France) in 3 consecutive months.Ten days after the third IM dose of Dipherelin ovarian stimulatio
Siemens Medical Solutions, California, USA) is performed every 4 days. After the observation of at least two 18mm follicles, HCG (Ferring Co, Germany, 10000IU, IM) is injected and after 36 hours oocyt
the rate of fertilization, laboratory and clinical pregnancy are compared between two groups. Intervention 2: Second group receives 3 consecutive single IM doses of Dipherelin 3.75mg (Beaufouipfen, Fr
Treatment - Drugs
Treatment - Surgery
First group receives 3 consecutive single IM doses of Dipherelin 3.75mg (Beaufouipfen, France) in 3 consecutive months.Ten days after the third IM dose of Dipherelin ovarian stimulation is conducted b
Second group receives 3 consecutive single IM doses of Dipherelin 3.75mg (Beaufouipfen, France) in 3 consecutive months after laparoscopic ovarian cystectomy. Ten days after the third IM dose of Diphe
Sponsors
Vice Chancellor for Research, Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Infertile women with endometrioma requiring assisted reproductive technology Exclusion criteria: Age over 40 years; Endometrioma smaller than 2 cm or larger than 6 cm; Male infertility TESE (Testicular Sperm Extraction) or PESA (Percutaneous Epididimal Sperm Aspiration)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of retrieved oocytes. Timepoint: 84 days after the first Dipherelin injection. Method of measurement: Invert Microscope, Diaphot 300, Nikon, Japan. | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of dominant follicles. Timepoint: 82 days after the first Dipherelin injection. Method of measurement: nGS= number of observed gestatinal sac in trans vaginal sonography, nET= number of embryonal transfer, clinical pregnancy rate(%)= nGS/ nET x100.;Fertilization rate. Timepoint: 87 days after the first Dipherelin injection. Method of measurement: nE= number of total embryos, nI= number of injected oocytes, fertilization rate(%)= nE/ nI x 100.;The number and quality of embryos. Timepoint: 87 days after the first Dipherelin injection. Method of measurement: Invert Microscope, Diaphot 300, Nikon, Japan.;Chemical pregnancy. Timepoint: 101 days after the first Dipherelin injection. Method of measurement: ßhCG test.;Clinical pregnancy rate. Timepoint: 115 days after the first Dipherelin injection. Method of measurement: nGS= number of observed gestatinal sac in trans vaginal sonography, nET= number of embryonal transfer, clinical pregnancy rate(%)= nGS/ nET x100. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Sedighe Hoseinimosa
Tehran University of Medical Sciences, Shariati Hospital, Department of Infertility
Outcome results
None listed