The comparison effects of intraarticular injection opioids (morphine, tramadole, methadone and pethidine) on postoperative pain relief after knee surgery (anterior cruciate ligament reconstruction)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201106102341N4

Enrollment

150

Registered

2011-09-04

Start date

2005-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain after knee anterior cruciate ligament reconstruction. Instability secondary to old ligament injury

Interventions

Intervention 1: Morphine group receives 0.5% bupivacaine with 1:200,000 epinephrine and 5mg morphine. Intervention 2: Methadone group receives 0.5% bupivacaine with 1:200,000 epinephrine and 5mg metha

Treatment - Drugs

Placebo

Morphine group receives 0.5% bupivacaine with 1:200,000 epinephrine and 5mg morphine

Methadone group receives 0.5% bupivacaine with 1:200,000 epinephrine and 5mg methadone

Pethidine group receives 0.5% bupivacaine with 1:200,000 epinephrine and 37.5 mg Pethidine

Tramadol group receives 0.5% bupivacaine with 1:200,000 epinephrine and 100 mg Tramadol.

Control group receives 0.5% bupivacaine with 1:200,000 epinephrine 0.5 ml normal saline.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: candidate of ruptured knee ACL reconstruction ; ASAI or ASAII class of American society of Anesthesiologist; Age between 18- 65 years old; Tolerance to general anesthesia and sign of informed consents. Exclusion criteria: history of allergic reaction to administered drugs in this study; history of drug abuse; history of chronic pain; consumption of MAOI agent ; using preoperative opioids or other analgesic drugs.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain after knee anterior cruciate ligament reconstruction. Timepoint: every 4 hours. Method of measurement: visual analouge score.	—

Secondary

Measure	Time frame
Pain relief and reduction of need to analgesics. Timepoint: every 4 hours. Method of measurement: visual analouge score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mahmood Mobasheri

Shahrekord University of Medical Sciences

pajoohesh@skums.ac.ir+98 38 1334 2414

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026