Childhood autism. Childhood autism
Conditions
Interventions
Intervention 1: Capsule Amantadine 100-150 mg/day+ Tablet Risperidon 1 to 3 mg/day as intervention 10 for 10 weeks. Intervention 2: Tablet Risperidone 1-3.5 mg/day +Capsule Placebo as control for 10
Treatment - Drugs
Placebo
Capsule Amantadine 100-150 mg/day+ Tablet Risperidon 1 to 3 mg/day as intervention 10 for 10 weeks
Tablet Risperidone 1-3.5 mg/day +Capsule Placebo as control for 10 weeks
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
3 Years to 12 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1-DSM IV clinical diagnosis of autistic disorder, 2-children between the ages of 3 and 11 years ,3- presence of behavioral problems such as aggression, overactivity or repetitive behaviors (indication of treatment with risperidone) Exclusion Criteria:1- Presence of any active medical problem, 2-any diagnosis in Axis I and II except for mental retardation, 3-history of allergy to Amantadine,4- receiving any psychotropic medications during past six weeks prior to the trial, 5-presence of hepatic disease, 6-history of seizure
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Autism severity. Timepoint: Baseline and weeks 5,10. Method of measurement: Aberrant Behavior Checklist-Community (ABC-C) Rating Scale.;Clinical Global Impression. Timepoint: Baseline and weeks 5 and 10. Method of measurement: CGI scale. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed