The Effect of evening primrose oil on Fertility outcomes in the women undergoing IVF treatment.

Study of the effect of evening primrose oil supplementation on fertility outcomes in the women undergoing IVF treatment: A triple blind randomized controlled trial.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110606006709N21

Enrollment

Registered

2020-01-15

Start date

2019-12-07

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group: In this study, 1000 mg capsule Evening Primrose oil containing 13% Gamalinolenic acid and 72% Linileic acid will be prepared by pharmacists of Barij Essence Kashan

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Women with primary and secondary infertility are candidates for IVF Women 20-40 years Women with a BMI between 18.5 and 29.9

Exclusion criteria

Exclusion criteria: Follow a specific dietary pattern for medical or other reasons History of seizures Malignancy Use of chemotherapy and radiotherapy or history of use corticosteroid drugs for up to one month Continuous and daily consumption of herbal yeas (borage ...) Tobacco and alcohol or any drug abuse IVF cycle = 4 Use of donated sperm or egg or frozen sperm and egg sever endometriosis Having uterine anomalies Use of blood thinners

Design outcomes

Primary

Measure	Time frame
Implantation rate. Timepoint: at week 5 of pregnancy will be calculated. Method of measurement: The implantation rate will be calculated by dividing the number of sacs visible in the ultrasound by the number of embryos transferred.;Fertility rate. Timepoint: One day after the IVF procedure will be determined. Method of measurement: Fertility rate It will be calculated as the number of fertilized oocytes divided by the total number of oocytes removed.	—

Measure

Time frame

Implantation rate. Timepoint: at week 5 of pregnancy will be calculated. Method of measurement: The implantation rate will be calculated by dividing the number of sacs visible in the ultrasound by the number of embryos transferred.;Fertility rate. Timepoint: One day after the IVF procedure will be determined. Method of measurement: Fertility rate It will be calculated as the number of fertilized oocytes divided by the total number of oocytes removed.

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Secondary

Measure	Time frame
Fetal quality status. Timepoint: On the third day after will be determined fertilization. Method of measurement: Third day, fetal quality under the microscope will be determined by an experienced person according to the fetal quality grading chart.;Pregnancy Test Status. Timepoint: 14 days after embryo transfer will be determined. Method of measurement: Clinical pregnancy as positive for blood ßHCG test will be specified.;Side Effects evening primrose oil supplementation. Timepoint: During the study will be reported. Method of measurement: By completing the checklist of side effects will be obtained.	—

Measure

Time frame

Fetal quality status. Timepoint: On the third day after will be determined fertilization. Method of measurement: Third day, fetal quality under the microscope will be determined by an experienced person according to the fetal quality grading chart.;Pregnancy Test Status. Timepoint: 14 days after embryo transfer will be determined. Method of measurement: Clinical pregnancy as positive for blood ßHCG test will be specified.;Side Effects evening primrose oil supplementation. Timepoint: During the study will be reported. Method of measurement: By completing the checklist of side effects will be obtained.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Sohrabi

Tabriz University of Medical Sciences

nahidsohrabi99@yahoo.com0984142263582

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026