schizophrenia. Schizophrenia
Conditions
Interventions
Intervention 1: ablet Risperidone (2-6 mg/day) combined with 2000 mg/day of Tablets N-acetyl cysteinel as intervention group for 8 weeks. Intervention 2: ablets Risperidone (2-6 mg/day) combined with
Treatment - Drugs
Placebo
ablet Risperidone (2-6 mg/day) combined with 2000 mg/day of Tablets N-acetyl cysteinel as intervention group for 8 weeks
ablets Risperidone (2-6 mg/day) combined with Tablets placebo as control group for 8 weeks
Sponsors
Tehran University of Medical Sciences
Kurdistan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1-Age between 18-50, 2-Diagnosis of Schizophrenia based on DSM IV 3-chronic Schizophrenia, 4-Minimum Score of 60 on Positive and Negative Scale exclusion criteria:1- Substance dependence,2- IQ <70,3-any other mental disorder on axis I, 4-Any serious medical or neurological problem ,5- receiving oral antipsychotic medications during the last week or receiving any depot antipsychotic medication during the last month,6- receiving ECT during the last 14 days 7-sensitivity to N-acetyl cysteine
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of schizophrenia. Timepoint: Baseline and weeks 2-4-6-8 after beginig of treatment. Method of measurement: Positive and Negative Syndrome Scale (PANSS). | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed