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Investigating the effect of vaginal probiotics on the consequences of embryo transfer, microbial culture of the uterine cavity and vagina in infertile women undergoing embryo transfer.

A comparative study of vaginal probiotic administration on the consequences of embryo transfer, microbial culture of the uterine cavity and vagina in infertile women undergoing frozen embryo transfer at Shariati Hospital, Tehran University of Medical Sciences.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20110602006689N5
Enrollment
156
Registered
2024-06-03
Start date
2024-06-23
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Microbial culture of the uterine cavity and vagina. Endometriosis

Interventions

Intervention 1: Intervention group: From the beginning of the embryo transfer cycle, Lactovage capsules are prescribed once vaginally for one month. Preparation of the endometrium with conjugated estr
Patients receive rectal progesterone suppositories for 4 days and then embryos with grade A, B and A-B are transferred. Intervention 2: Control group: Lactovagin suppositories are not given to the con
Patients receive rectal progesterone suppositories for 4 days and then embryos with grade A-B, A and B are transferred.

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Infertile women between the ages of 18 and 40 are candidates for frozen embryo transfer Not suffering from diseases such as liver disease, heart disease, kidney disease, diabetes, nervous system diseases, defects, immune system, sexually transmitted diseases No history of any surgery on the uterus and cervix Absence of uterine anomalies Having normal menstrual cycles (between 21 and 35 days)

Exclusion criteria

Exclusion criteria: Smoking and alcohol use male infertility Autoimmune diseases, uterine fibroids > 4 cm Uterine anomalies History of any surgery on the uterus and cervix Over 40 years old Presence of fibroma with pressure effect on endometriosis History of three unsuccessful embryo transfers Use of broad-spectrum antibiotics, hormonal drugs, anticoagulants, and immunosuppressive drugs and corticosteroids during the last month.

Design outcomes

Primary

MeasureTime frame
Diversity of microbial cultures of the uterine cavity and vagina. Timepoint: Before and after the intervention. Method of measurement: Microbial culture.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Sedighe Hoseinimosa

Tehran University of Medical Sciences

hoseinimosa@razi.tums.ac.ir+98 21 8800 8810

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: May 7, 2026