The effect of oxymetazoline nasal drops on cough, sore throat and bleeding in children after surgery

Investigating the effect of half percent oxymetazoline nasal drops on cough, sore throat and bleeding in children after tonsillectomy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110528006617N7

Enrollment

Registered

2022-08-16

Start date

2022-09-22

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tonsillectomy surgery. Chronic tonsillitis

Interventions

Intervention 1: Intervention group: In this group, 0.5% Oxymetazoline nasal spray (Raha Pharmaceutical Company) is prescribed as one puff in each nostril immediately after the induction of anesthesia.

Eligibility

Sex/Gender

All

Age

6 Years to 12 Years

Inclusion criteria

Inclusion criteria: Candidate for tonsillectomy surgery Ages between 6-12 years American Society of Anesthesiology (ASA) classification equal to I or II Parents' consent to participate in the study

Exclusion criteria

Exclusion criteria: Having hypertension Sensitivity to oxymetazoline Children who received analgesics, anti-nausea, asteroids, and antihistamines during the 15 hours prior to surgery Taking painkillers, antinausea, steroids, and antihistamines within 15 hours before surgery

Design outcomes

Primary

Measure	Time frame
Bleeding rate. Timepoint: During surgery and hospitalization in the ward. Method of measurement: Measuring the suction bottle and weightening of bloody gazes.;Sore throat. Timepoint: upon entering the recovery room and at minutes 15, 30, 45, and 60 of recovery as well as upon entering the ward and minutes 15, 30, 45, and 60 being in the ward. Method of measurement: Visual Analogue Scale (VAS).;Cough. Timepoint: From admission to recovery room until 24 hours after extubation. Method of measurement: Observational.	—

Measure

Time frame

Bleeding rate. Timepoint: During surgery and hospitalization in the ward. Method of measurement: Measuring the suction bottle and weightening of bloody gazes.;Sore throat. Timepoint: upon entering the recovery room and at minutes 15, 30, 45, and 60 of recovery as well as upon entering the ward and minutes 15, 30, 45, and 60 being in the ward. Method of measurement: Visual Analogue Scale (VAS).;Cough. Timepoint: From admission to recovery room until 24 hours after extubation. Method of measurement: Observational.

—

Secondary

Measure	Time frame
Heart rate. Timepoint: The beginning of recovery and at minutes 15, 30, 45, and 60 of recovery. Method of measurement: Monitoring device.;Systolic blood pressure. Timepoint: The beginning of recovery and at minutes 15, 30, 45, and 60 of recovery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: The beginning of recovery and at minutes 15, 30, 45, and 60 of recovery. Method of measurement: Monitoring device.	—

Measure

Time frame

Heart rate. Timepoint: The beginning of recovery and at minutes 15, 30, 45, and 60 of recovery. Method of measurement: Monitoring device.;Systolic blood pressure. Timepoint: The beginning of recovery and at minutes 15, 30, 45, and 60 of recovery. Method of measurement: Monitoring device.;Diastolic blood pressure. Timepoint: The beginning of recovery and at minutes 15, 30, 45, and 60 of recovery. Method of measurement: Monitoring device.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrdad masoudifar

Esfahan University of Medical Sciences

masoudifar@med.mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026