General anesthesia. Intervertebral disc disorders with myelopathy, lumbar region
Conditions
Interventions
Intervention 1: Intervention group: The first intervention group(Tranexamic acid) receive 600mg oral Tranexamic acid and one placebo tablet 2 hour before surgery. Induction of anesthesia with 0/05mg/k
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 20 – 65 year patients who consent to the informed consent to participate in the study ASA class 1 ,2
Exclusion criteria
Exclusion criteria: Beta blocker and Calcium blocker usage sedative drugs usage Opioids usage addiction to Alcohol allergic reaction to drugs allergic reaction to Local anesthetic drugs history of lumbar surgery risk factor of thrombosis anticoagulants drugs usage Digoxin usage Aspirin uage
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic Blood Pressure. Timepoint: Basic time(two hours before surgery), before anesthesia induction, 1,3,5,10,15 min after anesthesia, every 15 min during surgery, in the time of patient enter to the recovery. Method of measurement: mmHg , SAADAT Sphygmomanometer monitoring.;Diastolic Blood Pressure. Timepoint: Basic time(two hours before surgery), before anesthesia induction, 1,3,5,10,15 min after anesthesia, every 15 min during surgery, in the time of patient enter to the recovery. Method of measurement: mmHg , SAADAT Sphygmomanometer monitoring.;Mean Artherial Pressure. Timepoint: Basic time(two hours before surgery), before anesthesia induction, 1,3,5,10,15 min after anesthesia, every 15 min during surgery, in the time of patient enter to the recovery. Method of measurement: mmHg , SAADAT Sphygmomanometer monitoring.;Heart rate. Timepoint: Basic time(two hours before surgery), before anesthesia induction, 1,3,5,10,15 min after anesthesia, every 15 min during surgery, in the time of patient enter to the recovery. Method of measurement: beat/min , SAADAT ECG monitoring.;Volume Of Blood Loss. Timepoint: enter to the recovery, export from recovery. Method of measurement: Milliliter,volume of blood in the suction, Bloody gas.;Surgeon Satisfaction. Timepoint: End of the surgery. Method of measurement: Likert Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypotension. Timepoint: Basic time(two hours before surgery), before anesthesia induction, 1,3,5,10,15 min after anesthesia, every 15 min during surgery, in the time of patient enter to the recovery. Method of measurement: mmHg, SAADAT Sphygmomanometer monitor.;Hypertension. Timepoint: Basic time(two hours before surgery), before anesthesia induction, 1,3,5,10,15 min after anesthesia, every 15 min during surgery, in the time of patient enter to the recovery. Method of measurement: mmHg, SAADAT Sphygmomanometer monitor.;Tachycardia. Timepoint: Basic time(two hours before surgery), before anesthesia induction, 1,3,5,10,15 min after anesthesia, every 15 min during surgery, in the time of patient enter to the recovery. Method of measurement: beat/min ,SAADAT ECG monitoring.;Bradycardia. Timepoint: Basic time(two hours before surgery), before anesthesia induction, 1,3,5,10,15 min after anesthesia, every 15 min during surgery, in the time of patient enter to the recovery. Method of measurement: beat/min ,SAADAT ECG monitoring. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehrdad Masoudifar
Esfahan University of Medical Sciences
Outcome results
None listed