The Effect of Dexmedetomidine and Midazolam on Hemodynamic Indices During Anesthesia

Evaluation and comparison of hemodynamic indices during head holding pinning in neurosurgery procedures in two groups receiving Dexmedetomidine and Midazolam (Isfahan, 1397)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110528006617N3

Enrollment

Registered

2019-05-06

Start date

2018-08-23

Completion date

Unknown

Last updated

2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anesthesia. Other complications of anesthesia

Interventions

Intervention 1: The first intervention group(Dexmedetomidine): Initially, for primary anesthetic, patients receive 2 mg / kg of propofol and 0.5 microgram per kilogram of atherocorum and fentanyl is i

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age between 20 and 70 years Patients who consent to the informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: Patients who are not allergic to anesthetic drugs. Patients who do not take anti hypertensive drugs to control their blood pressure. Patients who do not receive the Nimodipin drug due to hemorrhage of the subaracnoide.

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-hg, sphygmomanometer.;Diastolic bllod pressure. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-hg, sphygmomanometer.;Mean arterial pressure. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-hg, sphygmomanometer.;Heart rate. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: ECG monitor.	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-hg, sphygmomanometer.;Diastolic bllod pressure. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-hg, sphygmomanometer.;Mean arterial pressure. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-hg, sphygmomanometer.;Heart rate. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: ECG monitor.

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Secondary

Measure	Time frame
Hypotension. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-Hg, sphygmomanometer.;Hypertension. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-Hg, sphygmomanometer.;Tachycardia. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: ECG monitor.;Bradycardia. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: ECG monitor.	—

Measure

Time frame

Hypotension. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-Hg, sphygmomanometer.;Hypertension. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: mm-Hg, sphygmomanometer.;Tachycardia. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: ECG monitor.;Bradycardia. Timepoint: Before intervention and 1 , 2 , 3 min after intervention. Method of measurement: ECG monitor.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrdad Masoudifar

Esfahan University of Medical Sciences

masoudifar@med.mui.ac.ir+98 913 316 2343

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026