Analgesic effects of opiates on neonates

Comparison of side effects of morphine and fentanyl in infants undergoing mechanical ventilation in the intensive care unit

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201105216532N1

Enrollment

Registered

2012-09-18

Start date

2012-08-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Distress Syndrome. Respiratory distress syndrome of newborn

Interventions

Intervention 1: 100mcg per kilograms morphine in 1 hours followed by 12 mcg per kilograms per hours intravenous morphine. Intervention 2: 2 mcg phentanyl per kilogram followed by 1.4 mcg per kilogram

Treatment - Drugs

100mcg per kilograms morphine in 1 hours followed by 12 mcg per kilograms per hours intravenous morphine

2 mcg phentanyl per kilogram followed by 1.4 mcg per kilogram per hours intravenously

Eligibility

Sex/Gender

All

Age

1 Years to 1 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Gestational age more than 24 weeks; Need for ventilation because of respiratory distress; Parents informed consent Exclusion criteria: Asphyxia; Hyperbilirubinemia; neonatal hepatitis; Biliary duct anomalies; Urinary system anomalies; cardiac anomaleis; gastroiuntestinal obstruction

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Systolic Blood Pressure. Timepoint: Baseline, 2nd day. Method of measurement: Mercury barometer.	—

Secondary

Measure	Time frame
Urinary retention. Timepoint: Baseline, 2nd Day. Method of measurement: Diagnosed by specialist.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Salma Naderi

Hormozgan University of Medical Sciences

salmanaderi@gmail.com+98 76 1333 7192

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026