Effect of Trachyspermum extract oral spray on ventilator associated pneumonia

Effect of Trachyspermum extract oral spray on incidence of pneumonia and oropharyngeal colonization in patients with mechanical ventilation hospitalized in intensive care units

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110514006481N16

Enrollment

Registered

2025-07-05

Start date

2025-07-12

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator Associated Pneumonia. Pneumonia in diseases classified elsewhere

Interventions

Intervention 1: Intervention group: A 10% Trachyspermum extract (manufactured by Tarbiat Modares Biochemistry Center) is used as two puffs of oral spray three times a day for six days after oral care.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Mechanical ventilation started in the past 24 hours No pneumonia No infection in the throat and mouth No aspiration No maxillofacial trauma

Exclusion criteria

Exclusion criteria: Weakness in the immune system Bronchoscopy Re-intubation Sores and sensitivity in the mouth

Design outcomes

Primary

Measure	Time frame
Ventilator Associated Pneumonia. Timepoint: First day and sixth day of study. Method of measurement: Modified Clinical Pulmonary Infection Score.;Oropharyngeal colonization. Timepoint: First day and sixth day of study. Method of measurement: Colony counting.	—

Secondary

Measure	Time frame
Oral hygiene. Timepoint: First day and sixth day of study. Method of measurement: Beck Oral Assessment Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad-ali Ahghari

Semnan University of Medical Sciences

mohammadaliahghari@gmail.com0098 23 3354191

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026