Effect of Synbiotic on gastrointestinal dysfunction in patients with mechanical ventilation

Study of the effect of nutrition with synbiotic compounds on prevention of gastrointestinal dysfunction in patients undergoing mechanical ventilation

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110514006481N12

Enrollment

Registered

2019-10-10

Start date

2019-10-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing mechanical ventilation

Interventions

Intervention 1: Intervention group: Compound of synbiotic (Lactocare) manufacture of Zeist-Takhmir pharmaceutical company, 500 mg twice daily for one week. Intervention 2: Control group: Sugar powder,

Eligibility

Sex/Gender

All

Age

30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Feeding through nasogastric tube. Mechanical ventilation for at least one week.

Exclusion criteria

Exclusion criteria: Third degree burns Gastrointestinal surgery Multiple organ dysfunction Post cardiac arrest Body mass index more than 35 Liver failure Use of drugs that affect gastrointestinal motility

Design outcomes

Primary

Measure	Time frame
Gastric residual volume. Timepoint: Before intervention and every day for a week. Method of measurement: Measure gastric residual volume with syringe.;Intra-abdominal pressure. Timepoint: Before intervention and every day for a week. Method of measurement: Through the urinary catheter by using a ruler.;Frequency of defecation. Timepoint: Before intervention and every day for a week. Method of measurement: Count frequency of defecation.	—

Measure

Time frame

Gastric residual volume. Timepoint: Before intervention and every day for a week. Method of measurement: Measure gastric residual volume with syringe.;Intra-abdominal pressure. Timepoint: Before intervention and every day for a week. Method of measurement: Through the urinary catheter by using a ruler.;Frequency of defecation. Timepoint: Before intervention and every day for a week. Method of measurement: Count frequency of defecation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Soleimani

Semnan University of Medical Sciences

Soli257@yahoo.com0098 23 3354192

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026