Effect of Vit C and Vit E on pain and TNF-a serum level in major surgery

Comparing the effect of vitamin C and vitamin E administration on pain and TNF-a serum level in patients undergoing major surgery with general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20110514006480N15

Enrollment

150

Registered

2018-07-08

Start date

2018-07-06

Completion date

Unknown

Last updated

2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

major surgery. Personal history of major surgery

Interventions

Intervention 1: Intervention group 1: Forty eight hours before anesthesia, 2 grams of vitamin C is prescribed. Intervention 2: Intervention group: Forty eight hours before anesthesia, 400 IU of vitami

Eligibility

Sex/Gender

All

Age

15 Years to 60 Years

Inclusion criteria

Inclusion criteria: All patients candidate for major surgery, longer than an hour (Including: open prostatectomy, hysterectomy, cystichema and cholecystectomy) The ASA physical status classification system in one or two classes

Exclusion criteria

Exclusion criteria: Prohibition of general anesthesia in patients History of taking any supplements or antioxidants before surgery such as vitamin C and vitamin E A history of taking any medication that interferes with the oxidant or antioxidant agents

Design outcomes

Primary

Measure	Time frame
Severity of pain. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: Visual analog scale.;Serum TNF-a levels. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: ELISA Kit.	—

Secondary

Measure	Time frame
Prothrombin Time. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: Prothrombin Time Test.;Partial Thromboplastin Time. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: Partial Thromboplastin Time Test.;International Normalized Ratio. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: International Normalized Ratio Test.;Bleeding Time. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: Bleeding Time Test.	—

Measure

Time frame

Prothrombin Time. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: Prothrombin Time Test.;Partial Thromboplastin Time. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: Partial Thromboplastin Time Test.;International Normalized Ratio. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: International Normalized Ratio Test.;Bleeding Time. Timepoint: Before the intervention, 6 hours after the completion of the surgery. Method of measurement: Bleeding Time Test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEbrahim PouryaMofrad

Shahre-kord University of Medical Sciences

rahim2019@yahoo.com+98 38 3226 4825

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026