Knee Osteoarthritis. Arthrosis
Conditions
Interventions
Intervention 1: Intervention group 1: topical use of 1% diclofenac gel (the tubes of 60 gram)
three times a day for six weeks and each time applied the gel over the site of interest for 3 to 5 minutes. Intervention 2: Intervention group 2: topical use of 1% H. helix extract 1% gel (the tubes
three times a day for six weeks and each time applied the gel over the site of interest for 3 to 5 minutes. Intervention 3: Control group: topical use of placebo (the tubes of 60 gram)
three times a day for six weeks and each time applied the gel over the site of interest for 3 to 5 minutes.
Sponsors
Shahre-kord University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: Primary osteoarthritis in at least one knee Having pain at least 2 weeks before treatment
Exclusion criteria
Exclusion criteria: Secondary osteoarthritis Active liver or kidney disease, peptic ulcer, diabetes, thyroid and parathyroid diseases, and coagulation disorders Consumed anticoagulant drugs History of ischemic or hemorrhagic stroke or deep vein thrombosis, history of local fractures, and deformities leading to osteoarthritis and articular diseases Allergy to any anti-inflammatory drug Alcohol abuse, drug abuse Used Corticosteroids of any type and other topical drugs at the site where the gel was applied, orally used other analgesics and other effective compounds for the treatment of osteoarthritis up to 10 days before beginning of the study Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of knee pain. Timepoint: Before as well as one, two, three, and six weeks after intervention. Method of measurement: Visual analog scale.;Morning stiffness. Timepoint: Before as well as one, two, three, and six weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index.;Daytime stiffness. Timepoint: Before as well as one, two, three, and six weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index.;Physical function. Timepoint: Before as well as one, two, three, and six weeks after intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMorteza Dehghani
Shahre-kord University of Medical Sciences
Outcome results
None listed