Effect of Nitroglycerin added to lidocaine in bier block

Evaluation the analgesic effect of Nitroglycerin added to lidocaine in intravenous regional anesthesia in hand Surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201105136465N1

Enrollment

Registered

2011-06-11

Start date

2010-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injury of muscle and tendon at wrist and hand level. Injury of muscle and tendon at wrist and hand level

Interventions

Intervention 1: Adding 200 microgram TNG plus 3 mg/kg lidocaine 2% dilute in 40 ml salin in nitroglycerine group. Intervention 2: Adding salin 40 ml as Placebo to 3 mg/kg lidocaine 2% in control grou

Treatment - Drugs

Placebo

Adding 200 microgram TNG plus 3 mg/kg lidocaine 2% dilute in 40 ml salin in nitroglycerine group.

Adding salin 40 ml as Placebo to 3 mg/kg lidocaine 2% in control group.

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 60 ASA I and II patients; candidate for hand and forearm surgeries (tendon injuries); under 90 min; aging from 18 to 50 years. exclusion criteria: sickle cell anemia; hypersensitivity; G6PD; Raynaud's disease; drug abuse history and addiction; and open fracture.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Sensory block onset time. Timepoint: Every thirty seconds to completion of sensory block. Method of measurement: Shortbeveled needle.;Motor block onset time. Timepoint: Every thirty seconds to completion of motor block. Method of measurement: Asking the subject to flex and extend his wrist and fingers.;Sensory recovery time. Timepoint: Every thirty seconds to return of sense in hand. Method of measurement: Shortbeveled needle.;Motor block recovery time. Timepoint: Every thirty seconds to complete movement of wrist. Method of measurement: Movement of wrist.	—

Measure

Time frame

Sensory block onset time. Timepoint: Every thirty seconds to completion of sensory block. Method of measurement: Shortbeveled needle.;Motor block onset time. Timepoint: Every thirty seconds to completion of motor block. Method of measurement: Asking the subject to flex and extend his wrist and fingers.;Sensory recovery time. Timepoint: Every thirty seconds to return of sense in hand. Method of measurement: Shortbeveled needle.;Motor block recovery time. Timepoint: Every thirty seconds to complete movement of wrist. Method of measurement: Movement of wrist.

—

Secondary

Measure	Time frame
Tourniquet time. Timepoint: Every 20 minutes to start of pain. Method of measurement: Visual analog scale (VAS) (0 cm _ “no pain” and 10 cm _ “worst pain imaginable.;Need to fentanyl. Timepoint: At the end of the surgery. Method of measurement: Microgram.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPooya Derakhshan

Tehran University Of Medical Sciences

pooyaderakh@yahoo.com+98 21 2242 1841

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026