Condition 1: Acute ST elevation myocardial infarction. Condition 2: Acute ST elevation myocardial infarction. Condition 3: Acute ST elevation myocardial infarction. Condition 4: Acute ST elevation myocardial infarction. ST elevation (STEMI) myocardial infarction of unspecified site ST elevation (STEMI) myocardial infarction of anterior wall ST elevation (STEMI) myocardial infarction of inferior wall ST elevation (STEMI) myocardial infarction of other sites
Conditions
Interventions
Intervention 1: Intervention group will receive 2 bolus doses of eptifibatide (Merk) with dose of 180mcg/kg with 10 minute interval. Then they will receive 2mcg/kg/min of eptifibatide infusion
totally 1 vial of 75mg/cc (short term protocol). Intervention 2: Control group: will receive 2 bolus doses of eptifibatide (Merk) with a dose of 180mcg/kg with a 10-minute intervals. Then they will re
Sponsors
Deputy of research and technology of Alborz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with symptoms of ischemic heart attack that last no longer than 12 hours with 1 mm ST elevation in at least 2 limb leads or 2 mm ST elevation in at least 2 precordial leads who are candidates for Primary PCI intervention.
Exclusion criteria
Exclusion criteria: Not acceptance of informed consent History of sensitivity to eptifibatide, heparin or aspirin Recent treatment with warfarin (INR>2), fibrinolythics or other IIbIIIa inhibitors Platelet 200mmHg, or DBP>110mmHg)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular or bleeding complication. Timepoint: During in-hospital admision. Method of measurement: Questionnaire and physical exam. | — |
Secondary
| Measure | Time frame |
|---|---|
| Death. Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file.;Myocardial infarction. Timepoint: 2 days and 6 months after intervention. Method of measurement: ECG and increase in CKMB.;Need for target lesion revascularization (TLR). Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file.;Need for target vessel revascularization (TVR). Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file.;Need for coronary artery bypass graft (CABG). Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file.;Cerebrovascular accidents. Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Fatemeh Sehati
?Alborz University of Medical Sciences
Outcome results
None listed