Non-alcoholic fatty liver. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
This study is a randomized, double-blind, placebo-controlled trial for 8 weeks. The participants are randomly assigned to the royal jelly or placebo arm (23 people in each group) without knowing about
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age 18 to 65 years diagnosis of NAFLD using ultrasound imaging Body mass index (BMI) 25 and above fasting blood sugar less than 126 no history of alcohol consumption or alcohol consumption less than 10 grams per day in women and less than 20 grams per day in men
Exclusion criteria
Exclusion criteria: Smoking history of liver, cardiovascular, pulmonary, kidney disease, celiac disease use of lipid-lowering drugs regular exercise six months before the study basic diet changes weight change of more than 5% in 3 months before screening History of gastric surgeries for weight loss patients using dietary supplements containing n-3 or n-6 fatty acids, vitamin D, E and other antioxidants or fiber supplements in the 12 weeks before the start of the study history of thyroid problems non-compliance Principles of the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TG?Total Cholestrol ? LDL ? HDL C ?ALT? AST ?GGT ? TNF a ? CRP. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: 5 cc of blood is taken to measure the concentration of liver enzymes, lipid profile, inflammatory factors and it is measured by enzymatic methods and using a kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight, body mass index (BMI), waist circumference, hip circumference, ratio of waist circumference to hip circumference, serum glucose, serum insulin, insulin resistance (HOMA-IR), quantitative insulin sensitivity index (QUICKI). Timepoint: At the beginning of the study and after 8 weeks after the intervention. Method of measurement: Taking blood samples using laboratory methods, the weight of each patient is measured with a scale with an accuracy of 100 grams, and the height of each patient without shoes is measured with a height meter with an accuracy of 0.5 cm. The body mass index (BMI) of the patients is calculated, the patient's waist and hips are measured using a tape measure with an accuracy of 0.5 cm, and finally, the body fat percentage of the patients is measured with an in-body device. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactfateme hasannia
Shahid Beheshti University of Medical Sciences
Outcome results
None listed