covid-19. COVID-19
Conditions
Interventions
Intervention 1: Intervention group: receiving alpha 1 antitrypsin drug. Type a 1-glycoprotein is a relatively small and polar molecule that acts as an extracellular inhibitor of serine proteases. This
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age above 18 years The presence of shortness of breath Positive PCR test for corona or lung involvement in imaging Signing informed consent and readiness to participate in the plan
Exclusion criteria
Exclusion criteria: Patients suffering from underlying diseases including pulmonary hypertension, kidney failure, seizures, depression, chronic hepatitis, cirrhosis and cholestatic liver diseases and pulmonary embolism (in the past 3 months) Use of anti-coagulant drugs such as warfarin, hormonal drugs and other illegal drugs (within the past 30 days) Alcohol consumption Pregnancy or breastfeeding Allergy to AAT drug Having IgA deficiency No smoking in the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ratio of neutrophils to lymphocytes. Timepoint: At the first and at the 4th week of the study. Method of measurement: immunoassay.;ESR. Timepoint: At the first and at the 4th week of the study. Method of measurement: Westergren method and ESR tube.;CRP. Timepoint: At the first and at the 4th week of the study. Method of measurement: Spectrophotometry.;IL-6. Timepoint: At the first and at the 4th week of the study. Method of measurement: immunoassay.;Mortality rate. Timepoint: the 4th week of the study. Method of measurement: observation.;Hospitalization time. Timepoint: the 4th week of the study. Method of measurement: observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdi shadnoush
Shahid Beheshti University of Medical Sciences
Outcome results
None listed