Nonalcoholic Fatty Liver Disease. Other specified inflammatory liver diseases
Conditions
Interventions
Intervention 1: Intervention group: for 12 weeks, 3-gram Spirulina per day from the Drotat high-tech and pharmaceutical science company in Iran. Intervention 2: Control group: for 12 weeks, 3-gram ma
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Age =18 years old, AST?>?38, ALT?>?40, Steatohepatitis grade 1,2 or 3 according to Ultrasound report, Having a history of alcohol consumption of less than 10 gram per day in women and less than 20 gram per day in men, Absence of other acute and chronic diseases and liver disorders (hepatitis B, C, etc.), biliary disease, known autoimmune diseases, cancer and inherited disorders affecting liver condition (storage disease of iron, and copper. ..), Hypertension, cardiovascular diseases, lung disease and kidney disease, cirrhosis, and celiac disease, Absence of pregnancy or lactation, Athletes or hospitalization, No consumption medications such as metformin, vitamin E and Ursodeoxycholic Acid (UDCA), No consumption hepatotoxic drugs such as phenytoin, tamoxifen and lithium, and corticosteroids and methotrexate, No consumption medications or antibiotics over a week during the study period or before entering it, No history of weight loss surgery in during year during, weight loss program during past 3-month, No history of hypothyroidism, Cushing's syndrome, and diabetes, Lack of gall bladder disease
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LDL-C. Timepoint: Beginning and end of the study. Method of measurement: Enzymatic method using a kit.;HDL-C. Timepoint: Beginning and end of the study. Method of measurement: Enzymatic method using a kit.;TG. Timepoint: Beginning and end of the study. Method of measurement: Enzymatic method using a kit.;Total Cholestrol. Timepoint: Beginning and end of the study. Method of measurement: Enzymatic method using a kit.;AST. Timepoint: Beginning and end of the study. Method of measurement: Enzymatic method using a kit.;ALT. Timepoint: Beginning and end of the study. Method of measurement: Enzymatic method using a kit.;Hepatic Steatosis. Timepoint: Beginning and end of the study. Method of measurement: Ultrasound.;Hs-CRP. Timepoint: Beginning and end of the study. Method of measurement: ELISA.;GSH. Timepoint: Beginning and end of the study. Method of measurement: ELISA.;Total antioxidant capacity. Timepoint: Beginning and end of the study. Method of measurement: ELISA.;FBS. Timepoint: Beginning and end of the study. Method of measurement: Enzymatic method using a kit.;HOMA-IR. Timepoint: Beginning and end of the study. Method of measurement: Calculation.;Weight. Timepoint: Beginning and end of the study. Method of measurement: Balance.;Body mass index. Timepoint: Begining and end of the study. Method of measurement: Calculation.;Leptin. Timepoint: Beginning and end of the study. Method of measurement: ELISA.;Lipopolysaccharides. Timepoint: Beginning and end of the study. Method of measurement: ELISA.;Waist circumstance. Timepoint: Beginning and end of the study. Method of measurement: tape. | — |
Secondary
| Measure | Time frame |
|---|---|
| Total Calorie Intake. Timepoint: Beginning and end of the study. Method of measurement: 3- days Recall Questionnaire.;Total Carbohydrate Intake. Timepoint: Beginning and end of the study. Method of measurement: 3- days Recall Questionnaire.;Total Protein Intake. Timepoint: Beginning and end of the study. Method of measurement: 3- days Recall Questionnaire.;Total Fat Intake. Timepoint: Beginning and end of the study. Method of measurement: 3- days Recall Questionnaire.;Total Fiber Intake. Timepoint: Beginning and end of the study. Method of measurement: 3- days Recall Questionnaire.;Total MUFA Intake. Timepoint: Beginning and end of the study. Method of measurement: 3- days Recall Questionnaire.;Total PUFA Intake. Timepoint: Beginning and end of the study. Method of measurement: 3- days Recall Questionnaire.;Total SFA Intake. Timepoint: Beginning and end of the study. Method of measurement: 3- days Recall Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdi Shadnoush
Shahid Beheshti University of Medical Sciences
Outcome results
None listed