Infertility. Female infertility
Conditions
Interventions
Intervention 1: In group I, 0.05mg subcutaneous Buserelin (suprefact, serono) was injected two times per day from the day 1 of cycle and HMG (Menogon, Ferring) 300 IU per day intramuscular from day 3
NV organon, oss, Netherlands) 10000 IU was injectod Intramuscular when at least 2 follicles = 18mm were noted on ultrasonography. Oocyte retrieval was scheduled 36 hours after hCG injection and conven
Treatment - Drugs
In group I, 0.05mg subcutaneous Buserelin (suprefact, serono) was injected two times per day from the day 1 of cycle and HMG (Menogon, Ferring) 300 IU per day intramuscular from day 3 of cycle. Follic
In group II, ovulation induction was performed with Buserelin (suprefact, serono) 0.5mg SC per day started on day 1 of cycle and continued for 3 consecutive days . HMG (menogon, ferring) 300 IU per da
Sponsors
Yazd Research and Clinical Center for Infertility
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: A history of one or more failed in IVF cycles which three or fewer oocytes were been retrieved or their serum steradiol’s level in day of HCG injection was 10 or age>40 years. Exclusion criteria: Body mass index higher than 30 and endocrine or metabolic disorder, endometriosis and severe male factor (azospermia ).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy. Timepoint: 2 weeks. Method of measurement: BhcG Test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of follicles. Timepoint: 15 days. Method of measurement: Numbering.;Quality of oocytes. Timepoint: 15 days. Method of measurement: Observation by microscope according to Good –postmature-degenerated.;The number of used gonadotropin ampoules. Timepoint: 15 days. Method of measurement: Numbering.;Quality of emberyo. Timepoint: 15 days. Method of measurement: According to the symmetrics and exact of Blastomer pieces.;Number of oocytes. Timepoint: 15 days. Method of measurement: Numbering.;Chemical pregnancy. Timepoint: after 14 days of embryo transfer. Method of measurement: Measurement of serum B-hCG.;Clinical pregnancy. Timepoint: 2-3 weeks after positive B-hCG. Method of measurement: observation of the fetal heart activity using a transvaginal ultrasonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Maryam Eftekhar
Research and Clinical Center for Infertility
Outcome results
None listed