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Evaluation of GnRH long-acting agonist protocols and GnRH antagonist protocol in controlled ovarian stimulation in in vitro fertilization in infertile women with poor ovarian response

Evaluation and comparison of GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF from POSEIDON group3- 4: A randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20110509006420N28
Enrollment
170
Registered
2024-01-30
Start date
2024-01-30
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: The GnRH antagonist group will start from the second day of the menstrual cycle, the ultrasound of gonadotropin IU225-300 rFSH signal-F daily subcutaneous injection. Then, if there is

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 42 Years

Inclusion criteria

Inclusion criteria: IVF/ICSI candidates Women who respond poorly to ovulation stimulation: ovarian reserve less than 1.2 ng/ml and AFC number less than 5 POSEIDON group 3-4 Women between the ages of 18 and 42

Exclusion criteria

Exclusion criteria: sever Asherman's history Severe uterine adenomyosis Egg donation cycles Cases of severe male infertility (azoospermia) Cases where surrogacy is used Endocrine or metabolic diseases (hypothyroidism, hyperthyroidism)

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy. Timepoint: 4 weeks after embryo transfer. Method of measurement: sonography.

Secondary

MeasureTime frame
Rate of early abortion. Timepoint: the loss of the gestational sac or fetal heartbeat in clinically pregnant individuals prior to 8 weeks of gestational age. Method of measurement: sonography.;??? ?????? ?????. Timepoint: the continuation of pregnancy after 12 wk of gestational age. Method of measurement: sonography.;Chemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: pregnancy test.;Implantation. Timepoint: After a positive pregnancy test. Method of measurement: sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactmaryam eftekhar

Yazd University of Medical Sciences

eftekhar@ssu.ac.ir+98 35 3824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026