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Endometrial preparation with tamoxifen in women with thin endometrium

Evaluation of pregnancy outcomes in frozen cycles following endometrial preparation with estrogen stair-step protocol compared with tamoxifen in women with thin endometrium

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20110509006420N25
Enrollment
60
Registered
2022-03-08
Start date
2022-03-11
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group: From day 3 to 7 cycles of 20 mg of tamoxifen are daily oral daily, and on day 10 ultrasound, if the dominant follicle was 14 and more, ultrasound repeatedly occurs

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Frozen embryo transfer candidate A history of thin endometrium less than 7 mm in the previous cycle BMI less than 30

Exclusion criteria

Exclusion criteria: Severe male infertility includes cases of azoospermia and sperm from TESE or PESA History of uterine surgery such as hysteroscopic surgery Use of coumarin anticoagulants DVT history History of pulmonary edema

Design outcomes

Primary

MeasureTime frame
Endometrial Thickness. Timepoint: Day 13 of the menstrual cycle. Method of measurement: Using ultrasound.;Chemical pregnancy. Timepoint: 15 days after embryo transfer. Method of measurement: Blood laboratory kit.;Clinical pregnancy. Timepoint: 3 weeks after positive beta-h Cg. Method of measurement: Observation of fetal heart activity by transvaginal ultrasonography.

Secondary

MeasureTime frame
Miscarriage rate. Timepoint: Loss of pregnancy before 20 gestational week. Method of measurement: Absence of fetal heart activity in ultra sound sonography.;Implantation rate. Timepoint: 3 weeks after positive beta-h Cg. Method of measurement: Calculated by the number of gestational sacs observed on ultrasound on the number of embryos transferred.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Eftekhar

Yazd University of Medical Sciences

eftekhar@ssu.ac.ir+98 35 1824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026