PCOS patients with clomid failure. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Intervention 1: 100 mg clomiphen citrate on days 3 to 7 of cycle and flutamid 250 mg per day from day 3 to the end of the menstrual cycle in the first cycle. Intervention 2: Interventi
Treatment - Drugs
Intervention 1: 100 mg clomiphen citrate on days 3 to 7 of cycle and flutamid 250 mg per day from day 3 to the end of the menstrual cycle in the first cycle
Intervention 2: 100 mg clomiphen citrate on days 3 to 7 of cycle and placebo from day 3 to the end of the menstrual cycle in the first cycle.
Intervention 3: 150 mg clomiphen citrate on days 3 to 7 of cycle and flutamid 250 mg per day from day 3 to the end of the menstrual cycle in the second cycle
Intervention 4: 150 mg clomiphen citrate on days 3 to 7 of cycle and placebo from day 3 to the end of the menstrual cycle in the second cycle.
Sponsors
Reproductive medicine research center, Royan Institute, ACECR
Eligibility
Sex/Gender
Female
Age
18 Years to 37 Years
Inclusion criteria
Inclusion criteria: Inclusion: Age under 37 years; PCOS diagnosed by the Rotterdam and legro and lanham criteria, by two of the following three features : 1) oligo or an ovulation, 2) clinical and or biochemical signs of hyper androgenism, or 3) polycystic ovaries; previously documented dominant follicle or follicles (R12mm mean diameter) on trans vaginal ultrasound follicular monitoring; normal uterine cavity and patent tubes by either hyserosalpin go gram or laparoscopy and hysteroscopy; normal fasting glucose; normal serum prolactione and thyroid stimulating hormone, estradiol, LH, testestron, normal semen analysis by world health organization criteria. Exclusion: Discontent of athending the study and being allergic to the intended drugs (Flutamid or clomiphene citrate); hyper prolactinemia; thyroid dysfunction; age over 37; and BMI >30.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improving ovulation, number of dominant follicles. Timepoint: number of dimnant follicles>18 mm in the mid cycle. Method of measurement: sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Regulating of cycles, during of stimulation. Timepoint: observation of follicles by sonography. Method of measurement: sonography and measurement of progestron in 19 th and 21 th cycle. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Shohreh Irani
Royan institute
Outcome results
None listed